Kawaki gave an interesting opinion in Boruto manga chapter 56, which is that if their body becomes Otsutsuki, they can also use the power of this clan.
Kawaki also suggested that Boruto should put Karma on someone.
1. Code
Currently, the strongest candidate for the container containing Boruto’s Karma seal is Code.
There is some doubt as to whether Code can become a vessel for Boruto’s Karma since he already has white Karma.
2. Uchiha Sasuke
Sasuke did not hesitate to sacrifice for what he thought was right.
Having Karma can also help Sasuke use space-time jutsu when he loses his Rinnegan.
It would be interesting if it turns out that Boruto in episode 1 is wearing Sasuke’s cloak and sword because he took over Sasuke’s body.
3. Uzumaki Naruto
Not everyone can withstand Otsutsuki’s power.
4. Mitsuki
This Mitsuki may be a unique Karma vessel.
5. Kawaki
Kawaki doesn’t have Karma now, but in the future he will have Karma.
So when Boruto reincarnated in Kawaki’s body, Kawaki reincarnated into another body, then a situation in Boruto episode 1 was created.